Modulation of Oxidative Stress Mediators in Adjuvant Induced Arthritis by Herbal Adaptogen <i>Boswellia serrata</i>

Authors

DOI:

https://doi.org/10.18311/ti/2018/v25i4/23085

Keywords:

Adjuvant Arthritis, Antioxidants, Boswellia serrata, Oxidative Stress

Abstract

A study was carried out to evaluate Boswellia serrata on adjuvant induced oxidative stress in rats. Intradermal administration of Freund's adjuvant to induce rheumatoid arthritis consequently produced oxidative damage as indicated by an increase in thiobarbituric acid reducing substances, myeloperoxidase, protein carbonyls and a reduction in superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in tissue homogenates. Oral administration of methanolic extracts ofBoswellia serrata at 500 mg/kg body weight re-established the antioxidant profile. Co-treatment with an anti-inflammatory agent, meloxicam showed an enhanced healing effect. Hence, a significant restorative effect was witnessed with the herbal adaptogen Boswellia serrata.

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References

Stills HF, Bailey MQ. The use of Freund's complete adjuvant.Lab Animal Science 1991; 20:25–31

Cho ML, Kim WU, Min SY, Min DJ, Min JK, Lee SH.Cyclosporine differentially regulates interleukin-10, interleukin15, and tumour necrosis factor α production by rheumatoid synoviocytes.Arthritis Rheum.. 2002; 46:42–51 https://doi.org/10.1002/1529-0131(200201)46:1<42::AIDART10026> 3.0.CO;2-A.

Mishafiey A, Cuzzocreay SB, Mazzony E, Saadat F, Stoude M. Treatment of experimental arthritis with M2000, a novel designed non-steroidal anti-inflammatory drug. Scand. J.Immunol. 2005; 61:435–41. https://doi.org/10.1111/j.13653083.2005.01594.x.PMid:15882435.

Tak PP, Zvaifler NJ, Green DR, Firestein GS. Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases. Immunol Today. 2000; 21:78–2. https://doi.org/10.1016/S0167-5699(99)01552-2.

Hitchon CA, El-Gabalawy HS. Oxidation in rheumatoid arthritis. Arthritis Research and Therapy 2004; 6:265– 78. https://doi.org/10.1186/ar1447. PMid:15535839.PMCid:PMC1064874

Cope AP. Studies of T-cell activation in chronic inflammation.Arthritis Research. 2002; 4:197–211. https://doi. org/10.1186/ar557. PMCid:PMC3273158

Gupta I, Parihar A, Malhotra P, Gupta S, Ludtke A, Safayhi H, Ammon HPT. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med. 2001; 67:391–5. https://doi.org/10.1055/s-2001-15802. PMid:11488449

Pandey RS, Singh BK, Tripathi YB. Extract of gum resins of Boswellia serrata inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property. Indian J. Exp. Biol.. 2005; 43:509–16.

Ross RMD. Therapeutic advantages of highly standardized Boswellia extracts. True Botanica. 2008; 1–37

Balasubramanian KA, Manohar M, Mathan VI. An unidentified inhibitor of lipid peroxidation in intestinal mucosa. Biochim Biophys Acta. 1988; 96:51–8. https://doi.org/10.1016/0005-2760(88)90094-X

Krawisz JF, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models. Gastroenterology 1984; 87:1344–50. https://doi.org/10.1016/0016-5085(84)90202-6.

Levine JD, Goetzl EJ, Basbaum AI. Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthritis. Rheumatic Disease of Clinics of North America. 1987; 13:369–83.

Madesh M, Balasubramanian KA. Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide.Indian Journal of Biochemistry and Biophysics. 1998; 35:184–0.

Asru KS. Colorimetric assay of catalase. Analytical Biochemistry. 1972; 47:389–94 https://doi.

org/10.1016/0003-2697(72)90132-7.

Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S transferase in rat lung and liver. Biochem Biophys Acta. 1979; 582:67–8.https://doi.org/10.1016/0304-4165(79)90289-7.

Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.Journal of Laboratory and Clinical Medicine. 1967; 70:158–69

Storey K. Oxidative stress: animal adaptations in nature.Brazilian Journal of Medical and Biological Research 1996; 29: 1715–33

Gambhir JK, Lali P, Jain AK. Correlation between blood antioxidant levels and lipid peroxidation in rheumatoid arthritis. Clinical Biochemistry. 1997; 30:351–5 https://doi.org/10.1016/S0009-9120(96)00007-0.

Okabe T, Hamaguchi K, Inafuku T, Hara M. Aging and superoxide dismutase activity on cerebrospinal fluid. J.Neurol. Sci.. 1996; 141:100–4. https://doi.org/10.1016/0022510X(96)00160-8

Hassan MQ, Hadi RA, Al-Rawi ZS, Padron VA, Stohs SJ.The glutathione defence system in the pathogenesis of rheumatoid arthritis. J Appl Toxicol. 2001; 21:69–73 https://doi.org/10.1002/jat.736.

Alessio HM, Blasi ER. Physical activity as a natural antioxidant booster and its effect on healthy life style. Research Quarterly for Exercise and Sports. 1997; 68:292–302. https:// doi.org/10.1080/02701367.1997.10608010. PMid:9421841

Darlington LG, Stone TW. Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. Br. J. Nutr. 2001; 85:251–69. https://doi.org/10.1079/ BJN2000239.

Visva KK, Premila A, Bina I. Alteration in antioxidant defence mechanisms in the small intestines of Methotrexate treated rat may contribute to its gastrointestinal toxicity. Cancer Therapy. 2007; 5:501–10.

Siess H. Oxidative stress: From basic research to Clinical Application. Am J Med. 1991; 91:38–85. https://doi.org/10.1016/0002-9343(91)90281-2.

Uhlig S, Wendal A. The physiological consequence of glutathione variations. Life Science. 1992; 51:1083–94. https:// doi.org/10.1016/0024-3205(92)90509-N.

Kohen R, Nyska A. Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions and methods for their quantification. Toxicol. Pathol. 2002; 30:620–50. https://doi.org/10.1080/01926230290166724.PMid:12512863

Doha AM, Sahar YA. In vivo evaluation of antioxidant and anti-inflammatory activity of different extracts of date fruits in adjuvant arthritis. Pol. J. Food Nutr. Sci. 2004; 13:397–402.

Ratheesh M, Shyni GL, Helen A. Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats.Inflammopharmacology 2009; 17:100–5. https://doi.org/10.1007/s10787-009-8044-0. PMid:19205849

Takeuchi K, Tanaka A, Ohno R, Yokota A. Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage. J Physiol Pharmacol. 2003; 54:165–82.

Lisa KS, Irada K, Joanna MT, Revathy S, Rufus T, Richard CH, Paul GW, Anthony JK. Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology. 2012; 51:1796–803. https://doi.org/10.1093/rheumatology/ kes193. PMid:22814531

Afsar V, Reddy M, Saritha KV. In-vitro anti-oxidant activity and anti-inflammatory activity of methanolic leaf extract of Boswellia serrata. International Journal of Biological and Pharmaceutical Research. 2012; 1:15–23.

Chevion M, Berenshtein E, Stadtman ER. Human studies related to protein oxidation: Protein carbonyl content as a marker of damage. Free Radical Research. 2000; 33:99–108.

Eduardo EMJ, Jose AOS, Andres C, Daniel CD, David J, Roberto G, Eduardo M, Cesar MA, Ronaldo HM, Enrique P. Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in kupffer and sinusoidal endothelial cells promoted by ischemia-reperfusion injury.Transplant International. 2011; 24:489–500. https://doi. org/10.1111/j.1432-2277.2010.01214.x. PMid:21261753

Published

2019-10-22

How to Cite

Divisha, R., Rani, M. U., Kumar, B. K., & Reddy, A. G. (2019). Modulation of Oxidative Stress Mediators in Adjuvant Induced Arthritis by Herbal Adaptogen <i>Boswellia serrata</i>. Toxicology International, 25(4), 193–197. https://doi.org/10.18311/ti/2018/v25i4/23085

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