Effect of Cadmium on Organ Biomarkers and Evaluation of Certain Adaptogens in Broilers


  • College of Veterinary Science, Rajendranagar, Department of Pharmacology and Toxicology,, Hyderabad, 500 030, India
  • College of Veterinary Science, Rajendranagar, Department of Pharmacology and Toxicology, Hyderabad, 500 030, India


Day-old male broiler chicks were randomly divided into 8 groups consisting of 10 chicks in each. Groups 1 and 2 were maintained as plain control and cadmium (100 ppm in feed) toxic control, respectively, for 6 weeks. Groups 3, 4 and 5 were maintained on a combination of cadmium along with Emblica officinalis (500 ppm in feed), vitamin E (300 ppm in feed) and polyherbal formulation (1 g/kg feed), respectively, for 6 weeks. Groups 6, 7 and 8 were maintained on cadmium for the first 4 weeks and on E. officinalis, vitamin E and polyherbal formulation, respectively, during the subsequent 2 weeks without cadmium. The biochemical parameters such as alanine transaminase (ALT), alkaline phosphatase (ALP), urea and creatinine were significantly (P<0.05) elevated in toxic control. These parameters revealed improvement following treatment with E. officinalis, vitamin E and polyherbal formulation in groups 6, 7 and 8, respectively. Thus, it is concluded that supplementation of E. officinalis, vitamin E and polyherbal formulation in feed is useful in preventing and treating the cadmiuminduced toxic effects.


Cadmium, Emblica officinalis, polyherbal formulation, vitamin E

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Uyanik F, Even M, Atasever A, Tuncoku G, Kolsuz AH. Changes in some biochemical parameters and organs of broilers exposed to cadmium and effect of zinc on cadmium-induced alterations. Israel J Vet Med 2001;56:128-34.

Watjen W, Beyersmann D. Cadmium induced apoptosis in C6 glioma cells: Influence of oxidative stress. Biometals 2004;17: 65-78.

Pereira ME, Svetlana Y, Gerald C. Disruption of the intracellular sulphydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells. J Biol Chem 1998;273:12703-9.

Kaneko JJ, Harvey JW, Michael LB. Clinical Biochemistry of Domestic Animals. 5th ed. New York: Academic press; 1997.

Demerdesh FM, Yousef MI, Kedwany FS, Baghdadi HH. Cadmium induced changes in lipid peroxidation, blood haematology, biochemical parameters and semen quality of male rats, Protective role of vitamin E and β-carotene. Food Chem Toxicol 2004;42:1563-71.

Bhattacharya A, Kumar M, Ghosal S, Bhattacharya SK. Effect of bio active tannoid principles of Emblica officinalis on iron induced hepatic toxicity in rats. Phytomed 2000;7:173-5.

Lee WK, Abouhamed M, Thevenod F. Caspase dependant and independent pathways for cadmium induced apoptosis in cultured kidney proximal tubule cells. Am J Physiol 2006;291:823-32.

Jianxun X, Zahir AS. Cadmium induced apoptosis in rat kidney epithelial cells involves decrease in nuclear factor- Kappa B activity. Toxicol Sci 2006;91:299-308.


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